Autoreactive T cells identified in patients with anti-Jo1+ antisynthetase syndrome recognise a new epitope on histidyl t-RNA synthetase
Autoreactive T-cells targeting a new HisRS epitope were identified indicating T cell reactivity to diverse epitopes of the HisRS protein in patients with anti-Jo1 autoantibodies. Furthermore, we demonstrated the TCR repertoire of autoreactive HisRS+CD4+T cells in patients. Persistence of these T-cells and specific clones may be contributing to disease.
Authors
- Ingrid E. Lundberg (ORCID: https://orcid.org/0000-0002-6068-9212)
- Anatoly Dubnovitsky (ORCID: https://orcid.org/0000-0002-5350-4531)
- Maryam Dastmalchi
- Adnane Achour (ORCID: https://orcid.org/0000-0003-0432-710X)
- Begum Horuluoglu (ORCID: https://orcid.org/0000-0003-2241-5170)
- Daniel Ramsköld (ORCID: https://orcid.org/0000-0003-2892-673X)
- Angeles S. Galindo‐Feria (ORCID: https://orcid.org/0000-0001-7095-211X)
- Genadiy Kozhukh (ORCID: https://orcid.org/0000-0003-4624-269X)
- Tatyana Sandalova (ORCID: https://orcid.org/0000-0002-7694-6420)
- Jamie Rossjohn (ORCID: https://orcid.org/0000-0002-2020-7522)
- Vivianne Malmström (ORCID: https://orcid.org/0000-0001-9251-8082)
- Juan Sebastian Diaz Boada
- Karine Chemin (ORCID: https://orcid.org/0000-0002-2597-7809)
- Annika van Vollenhoven
- Ravi Sharma (ORCID: https://orcid.org/0000-0002-2658-0002)
- Hugh H. Reid
- Christina Gerstner (ORCID: https://orcid.org/0009-0003-4342-4241)
Institutions
- Karolinska University Hospital (SE)
- Science for Life Laboratory (SE)
- Australian Regenerative Medicine Institute (AU)
- Karolinska Institutet (SE)
- Institute of Infection and Immunity (CA)
- Monash University (AU)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.ard.2025.09.015
- Citations
- 2
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Myositis Association
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Akademiska Sjukhuset
- Uppsala Universitet
- Science for Life Laboratory
- Uppsala Multidisciplinary Center for Advanced Computational Science