Insulin resistance-related indices, genetic risk, and the risk of cardiovascular disease in individuals with preclinical or clinical obesity: a large prospective cohort study in the UK biobank
Elevated IR-related indices, particularly TyG-WC, were associated with increased total CVD and CAD risks in preclinical or clinical obesity. Additive effects of TyG-WC and genetic risk on CVD were revealed, with mediating biomarkers suggesting potential targeted interventions for CVD risk reduction.
Authors
- Jinling Hu
- Cong Shang
- Yueqing Huang (ORCID: https://orcid.org/0000-0002-3443-5147)
- Chaonan Sun (ORCID: https://orcid.org/0009-0000-8319-7256)
- Jing Zhang (ORCID: https://orcid.org/0009-0001-5370-0014)
Institutions
- Suzhou Municipal Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1186/s12933-025-02961-9
- Citations
- 7
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 12.72