Spider Silk–Integrated Biomimetic Micropillars With Dual Adhesion for Improved Wound Hemostasis and Healing

Abstract Bionic adhesion‐based medical adhesives have proven effective in wound treatment, with current research addressing challenges such as weak adhesion and complex fabrication for broader applications. Herein, this work presents a bionic micropillar (MP) for monitoring wound therapy inspired by the physical and chemical properties of gecko toe pads and spider web mucus. Selective incompletely polymerized MP patches are prepared via a simple mold‐flipping method, in which spider silk proteins are incorporated into the micropillar matrix. In this design, free silicon–oxygen bonds on the surface spontaneously form physicochemical dual adhesions with the tissue surface, while the spider silk proteins enhance the mechanical stability and biocompatibility. The close adhesion of the patches to the tissue surface, the precise manipulation of fluids by the micropillar channels, and the sensitive response of the patches to small motion changes result in MP patches with excellent data collection and wound status monitoring capabilities. In vivo experiments have demonstrated that MP patches can effectively promote wound healing through efficient wound closure and outstanding biocompatibility. It can thus be concluded that physical and chemical synergistic biomimetic MPs, which integrate spider silk proteins, can be easily prepared, exhibit strong adhesion, and hold significant potential for clinical wound therapy.