Gamma sensory stimulation in mild Alzheimer's dementia: An open‐label extension study
Five mild Alzheimer's disease (AD) patients safely used daily 40 Hz audiovisual stimulation for 2 years. Late-onset AD (LOAD) patients showed increased 40 Hz electroencephalography (EEG) power and improved cognitive scores. National Alzheimer's Coordinating Center (NACC) data enhanced early-phase analysis and support precision medicine in AD studies. Plasma pTau217 declined in 2 LOAD patients after 2 years of daily use. This small pilot is the first to link long-term 40 Hz therapy to AD biomarker change.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- Michael Brickhouse
- S. R. Arnold (ORCID: https://orcid.org/0000-0002-4881-5685)
- Esperanza Martínez Ruiz
- Emery N. Brown (ORCID: https://orcid.org/0000-0003-2668-7819)
- Elizabeth B. Klerman (ORCID: https://orcid.org/0000-0002-7402-3171)
- Brennan Jackson
- Erin Kitchener
- Ute Geigenmüller
- Diane Chan (ORCID: https://orcid.org/0000-0003-3765-190X)
- Noah Milman (ORCID: https://orcid.org/0000-0003-0688-0427)
- Li‐Huei Tsai (ORCID: https://orcid.org/0000-0003-1262-0592)
- Ho‐Jun Suk (ORCID: https://orcid.org/0000-0002-0899-6709)
- R. Philips
- Vanesa S. Fernandez Avalos
- Gabrielle de Weck
- Pia Kivisäkk (ORCID: https://orcid.org/0000-0001-9708-7509)
- Bradford C. Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Bruno L. Hammerschlag
- Edward S. Boyden
- Monica Zheng
- AJ Becker
- Kenji Aoki (ORCID: https://orcid.org/0000-0001-7003-1994)
- Rosalind Mott Firenze
- M. J. Quay
Institutions
- Broad Institute (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- McGovern Institute for Brain Research (US)
- William James College (US)
- Oregon Health & Science University (US)
- Massachusetts General Hospital (US)
- New England School of Photography (US)
- Institute of Cognitive and Brain Sciences (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70792
- Citations
- 5
- Primary Topic
- Multisensory perception and integration
- Type
- article
- Field-Weighted Citation Impact
- 10.59
Funders
- Harvard Catalyst
- Robert A. and Renee E. Belfer Family Foundation
- Strong
- National Institutes of Health