Effect of Oxidative Stress on the Structure of Glutamate Receptors and Membranes in Neural Cells

A model approach is proposed for analyzing the properties of hippocampal neural networks containing modified glutamate receptors. Molecular dynamics modeling of the NMDA receptor-lipid system containing oxidized amino acid residues and damaged lipid molecules caused by free radicals was carried out. The network activity of neurons with a modified receptor structure was studied in the neural network model of the hippocampus’ CA3 region. As a result of studying the hippocampal neural network properties with a glutamate receptors modified structure, electrophysiological characteristics of the neural network model were obtained depending on the receptor ion channel structure. Based on the analysis of the ion channel conductivity and the nature of Mg $$^{{2 + }}$$ ion binding in the channel, differences in the amplitude of the theta and gamma frequency ranges were revealed in neural networks with NMDA receptors various model structures. In the course of the present study, the values of the hippocampal neural network collective rhythms (theta and gamma) were determined during the system oxidative modification and changes in the model neural population local potential were revealed depending on the localization and damage type in the receptor structures and phospholipid membrane.