Contactless longitudinal monitoring in the home characterizes aging and Alzheimer's disease–related night‐time behavior and physiology
Continuous monitoring reveals dementia-specific nocturnal sleep disturbances. We developed a novel sleep biomarker, Dementia Research Institute Sleep Index (AD), for tracking Alzheimer's disease (AD) progression. We used contactless under-mattress sensors for low-burden, long-term data collection. Prolonged bedtimes and frequent exits were identified as key dementia-related sleep traits. We demonstrated the feasibility of in-home monitoring for dementia care and risk assessment.
Authors
- Anna Joffe
- Magdalena Kolanko (ORCID: https://orcid.org/0000-0002-0058-5884)
- Benjamin Vittrant (ORCID: https://orcid.org/0000-0001-5578-7283)
- Ciro della Monica (ORCID: https://orcid.org/0000-0003-0422-4872)
- Ramin Nilforooshan (ORCID: https://orcid.org/0000-0001-9801-183X)
- David Sharp (ORCID: https://orcid.org/0000-0003-4995-2240)
- Mara Golemme (ORCID: https://orcid.org/0000-0001-9008-6845)
- Martina Del Giovane (ORCID: https://orcid.org/0000-0002-3476-8494)
- Eyal Soreq (ORCID: https://orcid.org/0000-0003-4809-4889)
- Kiran K G Ravindran (ORCID: https://orcid.org/0000-0003-3051-0266)
- Paul de Villèle (ORCID: https://orcid.org/0000-0003-4419-7557)
- Sarah Daniels (ORCID: https://orcid.org/0000-0002-7415-1907)
- Victoria L. Revell (ORCID: https://orcid.org/0000-0002-8809-4587)
- David Wingfield (ORCID: https://orcid.org/0000-0001-5331-0684)
- Derk‐Jan Dijk (ORCID: https://orcid.org/0000-0001-5314-1008)
- Helen Lai (ORCID: https://orcid.org/0000-0002-1600-8440)
- Chloe Walsh (ORCID: https://orcid.org/0009-0009-0516-9634)
- Marie‐Ange Stefanos
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Hammersmith Hospital (GB)
- University of Surrey (GB)
- Sorbonne Paris Cité (FR)
- UK Dementia Research Institute (GB)
- Issy Media (France) (FR)
- NeuroDiderot (FR)
- Surrey and Borders Partnership NHS Foundation Trust (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70758
- Citations
- 3
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.35