Comparison of amyloid chronicity and EYO in autosomal dominant Alzheimer's disease
Amyloid chronicity predicts a 14-year preclinical AD phase in ADAD. SILA accurately estimates age at A+ (MAE < 2 years). EYO outperforms chronicity in predicting symptom onset. APP mutation carriers show atypical amyloid accumulation. Chronicity models help reveal AD heterogeneity in preclinical stages.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Nicole S. McKay (ORCID: https://orcid.org/0000-0003-4123-2548)
- Jee Hoon Roh (ORCID: https://orcid.org/0000-0002-3243-0529)
- Mathias Jucker (ORCID: https://orcid.org/0000-0001-9045-1072)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Randall John Bateman (ORCID: https://orcid.org/0000-0002-7729-1702)
- Christopher R S Belder (ORCID: https://orcid.org/0009-0000-0472-870X)
- David Fernando Aguillon (ORCID: https://orcid.org/0000-0003-2283-536X)
- Carlos Cruchaga (ORCID: https://orcid.org/0000-0002-5261-689X)
- Peter R Millar (ORCID: https://orcid.org/0000-0003-4588-739X)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Stephanie A. Schultz (ORCID: https://orcid.org/0000-0001-8460-4415)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Julie K. Wisch (ORCID: https://orcid.org/0000-0003-3624-2784)
- Patricio Chrem
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Guoqiao Wang
- Igor Yakushev (ORCID: https://orcid.org/0000-0003-4764-798X)
- Laura Ibáñez (ORCID: https://orcid.org/0000-0003-2381-7059)
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Yan Li (ORCID: https://orcid.org/0000-0001-7402-0782)
- Natalie S. Ryan (ORCID: https://orcid.org/0000-0003-0361-7455)
- Mike Murphy (ORCID: https://orcid.org/0000-0002-8379-3813)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- Cliff R Jack
- Suzanne E. Schindler
- Chengjie Xiong
Institutions
- Royal Adelaide Hospital (AU)
- Mayo Clinic (US)
- University of Wisconsin–Madison (US)
- Morpho (United States) (US)
- Washington University in St. Louis (US)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- TUM Klinikum (DE)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- Queen Elizabeth Hospital (AU)
- Hope Center for Neurological Disorders (US)
- Mayo Clinic in Arizona (US)
- UK Dementia Research Institute (GB)
- Hertie Institute for Clinical Brain Research (DE)
- Mayo Clinic in Florida (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Korea University (JP)
- University College London (GB)
- The University of Adelaide (AU)
- University of Tübingen (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70812
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Foundation for Barnes-Jewish Hospital
- Japan Agency for Medical Research and Development
- Hope Center for Neurological Disorders
- University College London
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Ministry of Science and ICT, South Korea
- Fleni
- Instituto de Salud Carlos III
- National Institute on Aging