The Role of METS-IR in Early Screening for Gestational Diabetes Mellitus in Chinese Women: A Two-Center Prospective Study
METS-IR shows promise for early GDM screening and is outperformed by TyG and HOMA-IR in predictive value. METS-IR in early pregnancy reflects metabolic dysregulation linked to GDM risk, yet its predictive utility is partially mediated by lipid and insulin abnormalities. While METS-IR offers clinical feasibility through routine measurements, TyG and HOMA-IR exhibit superior independent predictive value. These findings highlight the importance of context-specific IR indices for early GDM risk stratification and underscore METS-IR's role as a composite marker of metabolically unhealthy obesity in pregnancy.
Authors
- Yanbei Duo (ORCID: https://orcid.org/0000-0002-9867-9087)
- Xiaorui Nie
- Qiujin Sun
- Zechun Lu
- Yong Fu (ORCID: https://orcid.org/0000-0001-6480-1147)
- Tao Yuan (ORCID: https://orcid.org/0000-0002-8923-0923)
- Shihan Wang (ORCID: https://orcid.org/0000-0001-6854-9217)
- Yuemei Zhang (ORCID: https://orcid.org/0000-0003-3555-4524)
- Weigang Zhao (ORCID: https://orcid.org/0000-0002-1472-7118)
- Jing Zhang (ORCID: https://orcid.org/0009-0003-9684-8654)
- Mengmeng Zhang (ORCID: https://orcid.org/0000-0002-4848-9568)
- Shuoning Song (ORCID: https://orcid.org/0000-0003-4810-4063)
- Yingyue Dong
- Xianchun Yang
- Wei Sun (ORCID: https://orcid.org/0009-0005-8101-5697)
- Junxiang Gao
- Xiaolin Qiao
- Ailing Wang
- Jiyu Xu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Hainan Maternal and Child Health Hospital (CN)
- National Center for Women and Children’s Health, China CDC (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/dmso.s538992
- Citations
- 1
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.06