Mechanism of LncRNA NORAD regulating ferroptosis in endometrial cancer cells by modifying GPX4 through FTO-mediated m6A methylation
NORAD was down-regulated in EC and affected the EC prognosis. NORAD overexpression facilitated YTHDF2-mediated m6A modification by interacting with FTO to elevate GPX4 degradation, thereby stimulating ECC ferroptosis and hindering EC progression.
Authors
- Zhen Shen (ORCID: https://orcid.org/0000-0002-6109-9775)
- Jieqi Ke
- Min Li (ORCID: https://orcid.org/0000-0002-3230-7678)
- Tianjiao Zhang (ORCID: https://orcid.org/0000-0001-9807-8620)
- Ting Gao (ORCID: https://orcid.org/0000-0002-3738-7988)
- Dabao Wu
Institutions
- University of Science and Technology of China (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1007/s00018-025-05855-x
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81