Investigation and Characterization of Clotting Artifacts in Coagulation Testing for the Development of Screening Criteria to Identify Clotted Plasma

Sample clotting substantially affects the accuracy of coagulation tests. Shortened APTT and elevated FMC and TAT serve as reliable indicators, with FDP and PIC offering time-sensitive supplementary clues. This multimodal approach could help standardize criteria for sample rejection and recollection, thereby improving test reliability and supporting clinical decisions.