Association of plasma p-tau217 levels with cerebral small vessel disease burden: Cross-sectional insights from the Hefei Aging Study
Plasma p-tau217 levels are associated with CSVD burden, particularly WMH and CMBs, suggesting a role for tau pathology in vascular injury. The APOE ε4 genotype appears to modulate this relationship, highlighting distinct pathways in amyloid- and tau-mediated vascular damage.
Authors
- Yiyuan Ge (ORCID: https://orcid.org/0009-0006-5442-1865)
- Xianzuo Zhang (ORCID: https://orcid.org/0000-0002-6432-7745)
- Yong-Kang Wang
- Xiang Fang
- Feng Gao (ORCID: https://orcid.org/0000-0002-7539-6455)
- Meng-Qi Luo
- Yi Li (ORCID: https://orcid.org/0000-0002-7068-0019)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6909-9649)
- Yong Shen (ORCID: https://orcid.org/0000-0002-5048-8134)
- Xiping Ding
- Yicheng Zhu (ORCID: https://orcid.org/0000-0003-0039-9210)
- Jun Wu
Institutions
- University of Science and Technology of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Anhui Provincial Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111602
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35