Cistus x incanus L. extract as a complex polyphenolic blend with retained anti-adhesive and anti-inflammatory properties in a model of E. coli-induced UTI following simulated digestion
These findings support, for the first time, the traditional use of Cistus x incanus in UTI, highlighting its ethnopharmacological relevance in the treatment of urinary infections. The mechanism of action, which includes anti-inflammatory and anti-adhesive activities of the extracts, has been investigated. The efficacy was observed at micromolar concentrations, which are supposed to be reached in vivo consuming Cistus x incanus food supplements. These findings lay groundwork for preclinical UTI models. Moreover, the outcomes in the present study warrant clinical investigations to consolidate our findings.
Authors
- Carola Pozzoli (ORCID: https://orcid.org/0000-0003-2107-3033)
- Beatrice Bruno
- Chiara Di Lorenzo (ORCID: https://orcid.org/0000-0002-2798-8720)
- Mario Dell’Agli (ORCID: https://orcid.org/0000-0001-5378-402X)
- Giovanna Baron (ORCID: https://orcid.org/0000-0002-9335-6318)
- Marco Fumagalli (ORCID: https://orcid.org/0000-0003-0119-7290)
- Giovanna Nicotra
- Enrico Sangiovanni (ORCID: https://orcid.org/0000-0003-2811-8628)
- Safwa Moheb El Haddad
- Nicole Maranta (ORCID: https://orcid.org/0009-0005-8416-1307)
- Silvia Francesca Vicentini
- Giulia Benedetta Martinelli (ORCID: https://orcid.org/0000-0002-0742-0521)
- Giancarlo Aldini (ORCID: https://orcid.org/0000-0002-2355-6744)
- Stefano Piazza (ORCID: https://orcid.org/0000-0002-2470-6038)
Institutions
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Human Technopole (IT)
- Epsilon (Italy) (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.jep.2025.120786
- Primary Topic
- Essential Oils and Antimicrobial Activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00