Sugar Rationing in the First 1000 Days After Conception and Long-term Risk of Metabolic Dysfunction-associated Steatotic Liver Disease and Major Adverse Liver Outcomes: A Natural Experiment Study
Early-life sugar restriction during critical developmental windows is associated with lower adult risk of MASLD and liver complications, primarily mediated by improved metabolic profiles. Policy efforts targeting sugar intake in pregnancy and early childhood may provide durable benefits for liver and metabolic health.
Authors
- Zhou Zhen (ORCID: https://orcid.org/0000-0003-0839-8802)
- Haisheng Wu (ORCID: https://orcid.org/0009-0000-4011-0704)
- Xianbo Wu (ORCID: https://orcid.org/0000-0002-2706-9599)
- Jiazhen Zheng (ORCID: https://orcid.org/0000-0003-0163-9175)
- Junchun Shen
- Jinghan Huang (ORCID: https://orcid.org/0000-0003-0628-6022)
- Daniel James Cuthbertson (ORCID: https://orcid.org/0000-0002-6128-0822)
- Qiang Tu (ORCID: https://orcid.org/0000-0002-8602-3347)
- Wenbo Huang
- Qi Qi (ORCID: https://orcid.org/0000-0003-3191-0544)
- Quan Yang (ORCID: https://orcid.org/0000-0002-9686-7578)
- Chuang Yang (ORCID: https://orcid.org/0000-0002-1405-0960)
Institutions
- The University of Sydney (AU)
- University of Liverpool (GB)
- Chinese University of Hong Kong (HK)
- Brown University (US)
- Bioscience (China) (CN)
- University of Tokyo Health Sciences (JP)
- University Hospital Leipzig (DE)
- University of Hong Kong - Shenzhen Hospital (CN)
- Merseytravel (GB)
- Liverpool Womens NHS Foundation Trust (GB)
- Monash University (AU)
- Southern Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Clinical Gastroenterology and Hepatology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.cgh.2025.10.015
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06