Language dysfunction and related amyloid-β in Alzheimer’s disease mediated by brain functional connectivity changes
Our findings showed that reduced fronto-temporal FCs mediated the association between amyloid-β burden and language dysfunction and further demonstrated the vulnerability of the left rpSTS in response to amyloid-β burden, which might lead to decreased FC with other regions.
Authors
- Xinyi Xie
- Wenwei Cao (ORCID: https://orcid.org/0009-0009-0526-9926)
- Nan Zhi (ORCID: https://orcid.org/0000-0002-1854-0940)
- Yaying Song (ORCID: https://orcid.org/0000-0002-3154-1235)
- Biao Li (ORCID: https://orcid.org/0000-0002-0493-2062)
- Gang Wang (ORCID: https://orcid.org/0000-0001-6500-5863)
- Jianping Li (ORCID: https://orcid.org/0000-0002-4859-1677)
- Jin‐Tao Wang (ORCID: https://orcid.org/0000-0002-6196-487X)
- Haixia Li (ORCID: https://orcid.org/0000-0003-0024-0971)
- Jin Wang (ORCID: https://orcid.org/0000-0002-1695-4875)
- Zhi Yang (ORCID: https://orcid.org/0000-0003-1958-482X)
- Jieli Geng (ORCID: https://orcid.org/0009-0004-0096-3402)
- Jiao Xiao
- Ru‐Jing Ren
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
- Beijing Anding Hospital (CN)
Publication Details
- Journal
- NeuroImage Clinical
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.nicl.2025.103893
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47