Divergent trajectories of inflammatory bowel disease in East, South, South-East and Central Asia: A comprehensive GBD 2021 analysis

Asia is experiencing a dual dynamic of expanding IBD caseload alongside improving survival and disability outcomes, with pronounced sub-regional heterogeneity. Demography remains the principal driver of case growth, but genuine increases in age-specific incidence signal ongoing propagation of risk. Strengthening surveillance, expanding equitable access to advanced therapies, and implementing region-specific, longitudinal care pathways are imperative to avert disproportionate future disability and economic loss.