Multimodal immune profiling of peripheral blood to predict the response to intra-articular autologous blood-derived orthobiologic treatment in patients with knee osteoarthritis
Early response to autologous blood-derived orthobiologic injections could be associated with specific inflammatory and oxidative stress markers and distinct peripheral blood T cell phenotypes of patients undergoing treatment. Further studies are warranted to validate these findings in larger cohorts at extended follow-up timepoints.
Authors
- Carlo Selmi (ORCID: https://orcid.org/0000-0002-0323-0376)
- Angela Ceribelli (ORCID: https://orcid.org/0000-0001-5116-4724)
- Berardo Di Matteo (ORCID: https://orcid.org/0000-0002-9807-0271)
- Antonio Tonutti (ORCID: https://orcid.org/0009-0000-9534-6853)
- Veronica Marrella (ORCID: https://orcid.org/0000-0003-4035-8106)
- Cristiano Sconza (ORCID: https://orcid.org/0000-0002-5345-9902)
- Emanuela Morenghi (ORCID: https://orcid.org/0000-0002-0254-3143)
- Chiara Camisaschi (ORCID: https://orcid.org/0000-0002-5205-919X)
- Cristina Sobacchi (ORCID: https://orcid.org/0000-0002-2684-7184)
- Simone Puccio (ORCID: https://orcid.org/0000-0003-4007-4365)
- Valentina Granata (ORCID: https://orcid.org/0000-0003-1560-378X)
- Giuseppe Filardo (ORCID: https://orcid.org/0000-0002-8136-0977)
- Nicola Rani
- Rita Ragusa
Institutions
- Humanitas University (IT)
- Institute of Genetic and Biomedical Research (IT)
- Orthopedic Institute (US)
- IRCCS Humanitas Research Hospital (IT)
- Università della Svizzera italiana (CH)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.biopha.2025.118674
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00