S215 Diabetes- and Pancreatitis-Related Mortality in the United States Population Aged ≥45 Years (2010 to 2020): Temporal Trends, Demographic Disparities, and Subtype-Specific Mortality Drivers

Introduction: Emerging data underscores the association of diabetes mellitus (DM) with pancreatitis. Our study identifies trends and disparities in DM with pancreatitis-related mortalities across the U.S. adult population with focus on the differences of acute and chronic pancreatitis (AP and CP) subtypes. Methods: We obtained data for adults aged ≥45 from the multiple causes of death files using CDC WONDER spanning 2010 to 2020. ICD-10 codes were used to identify mortality cases. Age-adjusted mortality rates (AAMRs) per 100,000 individuals were categorized as per demographic and regional distribution, and Joinpoint regression analysis was performed to calculate annual percent changes (APCs) with 95% confidence intervals (CIs). Results: From 2010 to 2020, pancreatitis and DM caused 9,857 deaths in U.S. adults aged ≥45. AAMRs for AP-DM and CP-DM increased, peaking in 2020 (AP-DM: 0.5771; CP-DM: 0.2702). CP-DM AAMRs rose significantly from 0.205 in 2015 to 0.270 in 2020 (APC: 6.25), while AP-DM surged from 0.422 in 2019 to 0.577 in 2020 (APC: 42.51). Overall, men had higher AAMRs than women; CP-DM- related AAMRs in men ≥65 increased from 0.3 (2017) to 0.519 (2020; APC: 17.33). Rural areas had higher AAMRs than urban areas. States with the highest AAMRs were Oklahoma (AP-DM: 1.072), West Virginia (AP-DM: 0.905; CP-DM: 0.383), and the District of Columbia (CP-DM: 0.502). Black and White populations had higher AAMRs, with sharp increases from 2019 to 2020 (Black APC: 47; White APC: 45.14). Conclusion: AP-DM contributed to more deaths than CP-DM across the decade. The highest AAMRs were observed in older men, urban populations, and African Americans/Blacks and Whites. The results suggest an increasing trend in mortality due to DM and pancreatitis, especially at the end of the decade. These findings emphasize the need for targeted interventions aimed at reducing mortality due to pancreatitis and DM, particularly among the susceptible populations.