S180 Impact of Age on Outcomes of Surgical Management for Pancreaticobiliary Malignancy: Implications for Gastroenterology Practice

Introduction: Numerous studies have established the significant impact of age on surgical outcomes. However, the effects of age on both long-term and short-term outcomes following the Whipple procedure need further investigation. This study is designed to systematically compare the outcomes of Whipple procedures performed on patients aged <65 and those who are >65. Methods: A retrospective chart review of all patients who underwent Whipple from 2010 to 2024. The study gathered data on patient demographics, duration of hospitalization, intraoperative complications, postoperative complications, 90-day, 1-year, 3-year, and 5-year mortality rates. Statistical analyses were performed using Student’s t-test and Chi-square test via JASP software. Results: Out of 238 adrenalectomies performed, 90, 37.8%, patients were below the age of 65, while 148, 62.16%, were above 65. There was a statistically significant difference in their BMI, with an average BMI of 29 in patients under 65 and 30 in patients over 65, yielding a P-value of 0.03. Additionally, there was a statistically significant difference in postoperative complications, with 30 (33.3%) complications in patients under 65 and 73 (49.3%) complications in those over 65, resulting in a P-value of 0.013. The reoperation rate also differed significantly between the 2 groups, with 4 (4.44%) reoperations in patients under 65 and 19 (12.8%) in patients over 65, and a P-value of 0.03. Finally, there was a significant difference in the 5-year mortality rate: 20 (22.2%) in the under-65 group compared to 59 (39.8%) in the over-65 group, with a P-value of 0.02. Conclusion: The Whipple procedure yields lower postoperative complications, a lower reoperation rate, and a lower 5-year mortality rate in patients aged under 65 compared to those over 65.