S418 Meta-Analysis of Robotic Endoscopic Submucosal Dissection for Colorectal Lesions

Introduction: Endoscopic submucosal dissection (ESD) of colorectal lesions can be technically challenging with a significant risk of adverse events. Few studies have shown improved outcomes with robotic ESD. We conducted a meta-analysis to reconcile the data. Methods: Online databases were searched for studies evaluating robotic ESD in patients with colorectal lesions. The outcomes of interest were technical success, en bloc resection, perioperative mortality, post ESD bleeding, and perforation. Pooled proportions were calculated along with 95% confidence intervals (CI). Results: A total of 3 studies with 86 patients were included. The mean age was 63 years and 63% of patients were men. The average procedure duration was 74 minutes, speed of dissection was 45 mm2/min, specimen size was 38.7 mm and duration of hospital stay was 1 day. The pooled clinical outcomes were: technical success 95.4% (95% CI 82.95 to 99.99), en bloc resection 96.7% (95% CI 88.69 to 99.95), post ESD bleeding 3.4% (95% CI 0.68 to 8.22), and perforation 2.0% (95% CI 0.15 to 6.00). No cases of perioperative mortality were reported. Conclusion: Robotic ESD for colorectal lesions showed a high en bloc resection rate with low risk of adverse events.