S464 Characteristics, Management, and Outcomes of Gastrointestinal Neuroendocrine Tumors in a Community Hospital Setting With a Predominantly Hispanic Population

Introduction: The incidence of gastrointestinal neuroendocrine tumors (GI-NETs) has increased with the broader use of advanced imaging and endoscopy. Despite this rise, variability exists in how these tumors are managed and surveilled. We aimed to evaluate the clinical features, treatment strategies, and outcomes of patients with GI-NETs at a single community hospital with a predominantly Hispanic population. Methods: We conducted a retrospective review of 44 patients diagnosed with GI-NETs between 2019 and 2024. Demographics, tumor characteristics, treatments, surveillance patterns, and clinical outcomes were analyzed. Categorical variables were summarized as frequencies and percentages; continuous variables were reported as means with standard deviations. Fisher’s exact test was used to assess the association between World Health Organization (WHO) tumor grade and recurrence. Results: The cohort included 44 patients with a mean age of 51.9 years (SD ± 13.42), 56.8% female, and 72.7% Hispanic/Latino. Rectal NETs were the most common, accounting for 65.9% (n = 29), with 84.1% (n = 37) of all tumors measuring ≤1 cm. WHO Grade 1 tumors predominated at 72.7% (n = 32), and metastases were observed in 14.6% (n = 6). Endoscopic resection was the primary treatment, with endoscopic full thickness resection (EFTR) in 39.5% (n = 15) and endoscopic mucosal resection (EMR) in 23.7% (n = 9). Locoregional therapies were used in 9.1% (n = 4) of cases, while systemic therapies were used in 4.5% (n = 2). Surveillance was conducted in 70.5% (n = 31) of patients, primarily through endoscopy (51.2%, n = 22), with a mean duration of 1.53 years (SD ± 0.94). Recurrence occurred in 10.3% (n = 3) of patients and was more frequent in higher-grade tumors (5.0% in G1, 14.3% in G2, and 100% in NEC; P = 0.056). The 5-year survival rate among patients with available long-term data was 80%. Conclusion: In this predominantly Hispanic cohort, most tumors were low grade and small, with excellent outcomes following endoscopic treatment. Recurrence was uncommon but was more frequently observed in cases with higher tumor grade, supporting the need for risk-adapted surveillance strategies.