S707 Clinical Outcomes for Patients With Thrombocytopenia and Early-Onset Colorectal Cancer: Further Analysis of the National Inpatient Sample

Introduction: Despite recent global decreases in overall cancer incidence, the incidence of early-onset colorectal cancer (EOCRC) is steadily increasing in western populations. Limited data is available on the comorbid correlations for this unfortunately expanding population. We sought to examine the national inpatient sample database to describe in-hospital outcomes among the thrombocytopenic population with EOCRC. Methods: Data were extracted from the National Inpatient Sample (NIS) Database for 2019 and 2020. The NIS was searched for hospitalizations of adult patients with EOCRC, defined as all-cause colorectal cancer in patients 50 years old or younger. We then examined the outcomes of patients who were identified as having thrombocytopenia. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality. SPSS software was used for statistical analysis. Results: This study included 11,820 patients with EOCRC, of which 727 (6.15%) were found to have thrombocytopenia. Thrombocytopenic patients had a higher prevalence of hypertension (5.64% versus 3.90%, P < 0.001) and chronic kidney disease (6.46% vs 4.20%, P < 0.001). Multivariate regression showed that thrombocytopenic patients with EOCRC had higher inpatient mortality (odds ratio [OR] 1.201, CI 1.143-1.261, P < 0.001). On secondary analysis, patients with thrombocytopenia and EOCRC were more likely to have anemia (OR 1.100, CI 1.090-1.110, P < 0.001), acute renal failure (OR 1.112, CI 1.093-1.133, P < 0.001), acute pancreatitis (OR 1.138, CI 1.058-1.224, P < 0.001), acute pericarditis (OR 1.103, CI 1.026-1.186, P < 0.001), esophagitis (OR 1.076, CI 1.063-1.089, P < 0.001), ulcerative colitis (OR 1.091, CI 1.002-1.188, P < 0.001), Crohn’s disease (OR 1.079, CI 1.029-1.132, P < 0.001), severe liver disease (OR 1.101, CI 1.090-1.111, P < 0.001), connective tissue disease (OR 1.200, CI 1.065-1.352, P < 0.001), all-cause arrhythmias (OR 1.117, CI 1.073-1.162, P < 0.001), all-cause shock (OR 1.165, CI 1.086-1.250, P < 0.001), all-cause sepsis (OR 1.131, CI 1.113-1.149, P < 0.001), all-cause coagulopathy (OR 1.201, CI 1.156-1.248, P < 0.001), all-cause heart failure (OR 1.114, CI 1.070-1.159, P < 0.001), all-cause stroke (OR 1.116, CI 1.071-1.163, P < 0.001), and all-cause myocardial infarction (OR 1.118, CI 1.057-1.183, P < 0.001). Conclusion: In this nationally representative, population‐based retrospective cohort study, thrombocytopenic patients with EOCRC were associated with higher mortality and worse outcomes.