S17 Comparative 1-Year Outcomes of Acute Kidney Injury and the Need for Hemodialysis in Patients With Acute Pancreatitis: Alcohol Users vs Non-Alcohol Users

Introduction: Acute pancreatitis (AP) can result in significant morbidity and mortality, particularly when associated with alcohol abuse. Acute kidney injury (AKI) and the need for hemodialysis are critical complications that can occur during the disease course. In this study, we aim to compare the 1-year outcomes of AP among alcohol abusers vs non-alcohol abusers on the renal system. Methods: We conducted a retrospective analysis of deidentified, aggregate patient data from TrinetX research network. The cohort comprised of patients 18 years old or older with diagnosis of AP. Patients were categorized into 2 cohorts: alcohol users and non-alcohol users. One-year outcomes including: AKI and the need for hemodialysis were compared between the 2 groups. Variables including age, gender, ethnicity, past medical history of diabetes mellitus, hypertension, metabolic syndrome, obesity, opioid and nicotine use known to cofound the association between the development of AP and composite outcomes. Thus, 1:1 propensity matching was used in this study. Cox proportional hazards regression analysis was also utilized to analyze the matched cohorts. Hazard ratios and 95% confidence intervals (95% CI) were reported in this analysis. Results: The study included 72,771 patients in both the alcohol user and non-alcohol user groups after propensity score matching. Patients with AP who abused alcohol had a significantly higher incidence of AKI compared to non-alcohol users (14.4% vs 9.7%, odds ratio = 1.565, 95% CI: 1.516-1.616, P < 0.001). Conversely, the need for hemodialysis was lower in the alcohol-abusing cohort (0.048% vs 0.100%, odds ratio = 0.479, 95% CI: 0.320-0.717, P < 0.001). Conclusion: Alcohol abuse in patients with AP was found to be associated with an increased risk of AKI. However, patients with alcohol-related AP had a lower likelihood of requiring hemodialysis compared to the other cohort. These findings highlight the importance of monitoring renal outcomes in patients with alcohol-related AP which may guide improvements in clinical management strategies.