S122 Groans and Stones: Chronic Pancreatitis and Urolithiasis: A National Inpatient Sample-Based Study

Introduction: Chronic pancreatitis is a chronic inflammation of the pancreas that is associated with significant morbidity and mortality. Some studies have postulated an increased risk of urolithiasis with chronic pancreatitis. Our study aimed to utilize the National Inpatient Sample database to evaluate the association between chronic pancreatitis and urolithiasis. Methods: A retrospective cohort analysis was done using the National Inpatient Sample database (2016 to 2017). The ICD-10 CM codes were used to identify hospitalized patients with chronic pancreatitis as the exposure of interest. The above population was then screened for urolithiasis. Adjustments were made for confounders of interest, including basic demographic data, Charlson comorbidity scores, obesity, and hospital characteristics. Multivariate logistic regression analysis models were constructed to calculate the adjusted odds ratio of urolithiasis among patients with chronic pancreatitis. Results: 370,774 hospitalizations with chronic pancreatitis were identified, of which 5562 (1.5%) were noted to have urolithiasis. Of the aforementioned population, 56.9% were men, 75.39% Caucasians, and 14.39% were African Americans. 45.87% had Medicare insurance, and 54.79% had a Charlson comorbidity index score of 2 or higher. Detailed baseline characteristics of the patients in the 2 groups are described in Table 1 [Tables presented at ACG annual meeting]. Chronic pancreatitis was found to have a significantly higher association with urolithiasis (aOR: 2.18, P-value < 0.001). After adjusting for confounders, age, higher BMI, hyperparathyroidism, and inflammatory bowel disease were found to be independently associated with urolithiasis. Conclusion: Our study reveals a significant association between chronic pancreatitis and urolithiasis. The proposed mechanism, linked to fat or bile acid malabsorption, underscores the importance of physician awareness and the potential for targeted prevention strategies. By implementing these strategies, we can potentially prevent urolithiasis and improve the overall morbidity and mortality in chronic pancreatitis.