Validation of the PEN‐FAST Penicillin Allergy Clinical Decision Rule in an Asian Cohort
The PEN-FAST clinical decision rule demonstrates a high NPV in an Asian population, supporting its potential utility in identifying individuals unlikely to have true penicillin allergy and enabling direct DPT in low-risk patients without prior ST. However, the modest area under the curve (AUC) of 0.66 reflects limited overall discriminatory ability.
Authors
- Justina Wei Lynn Tan (ORCID: https://orcid.org/0000-0002-2849-3287)
- Gabriel Chan (ORCID: https://orcid.org/0000-0002-0997-1028)
- Bernard Yu‐Hor Thong (ORCID: https://orcid.org/0000-0002-6338-8482)
- Khai Pang Leong (ORCID: https://orcid.org/0000-0003-4060-5525)
- Xin Rong Lim (ORCID: https://orcid.org/0000-0002-1167-353X)
- Ryan Xuan Wei Teo
- Seunghyun Lee (ORCID: https://orcid.org/0000-0001-9254-183X)
- Sze‐Chin Tan
- Faith Li‐Ann Chia
- Claire Min‐Li Teo (ORCID: https://orcid.org/0000-0002-0384-1740)
Institutions
- Tan Tock Seng Hospital (SG)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1111/cea.70164
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00