S151 Racial Disparities in Head of Pancreas Cancer: A SEER Database Analysis

Introduction: Eighty percent of pancreatic cancers originate at the head of the pancreas and are highly metastatic due to it being diagnosed later on in the disease course. We hope to explore and highlight some of the racial disparities that impact survival in patients diagnosed with head of pancreas cancer. Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results Database was used to identify non-Hispanic White, Black, Asian, Hawaiian, and Pacific Islander (AAPI) patients diagnosed with malignant, histologically confirmed pancreatic head cancers between 1975 and 2021. A pair plot and scatter-plot with a regression line were used to analyze racial disparities in survival outcomes. Results: A Survival outcomes in male patients with pancreatic head cancer revealed significant racial disparities: At 12 months, a statistically significant difference in survival was observed between White and Black groups (P = 0.000257, z = -3.47), though the magnitude of this disparity decreased at subsequent time points. Comparisons between White and AAPI groups demonstrated significant differences at 12 months (P = 0.032, z = 2.13), 36, 48, and 60 months (P = 0.003, 0.047, and 0.023, respectively). The analysis of Black vs AAPI populations revealed significant differences across all time points, beginning at 12 months (P = 0.000029, z = 4.02). Conclusion: Black men demonstrated significantly lower survival rates than White men at various time points, while White populations exhibited better survival outcomes compared to AAPI groups. Black populations showed better survival than AAPI groups. The long-term mortality between Black and White groups diminished over time, suggesting evolving dynamics in racial disparities. These findings underscore persistent racial disparities in pancreatic head cancer outcomes and highlight the need for targeted interventions that address healthcare access, socioeconomic barriers, and treatment disparities to improve survival across all populations.