Concomitant Cardiac Transthyretin Amyloidosis and Coronary Artery Disease---Imaging Features and Pitfalls

The coexistence of coronary artery disease (CAD) and transthyretin cardiac amyloidosis (ATTR-CM) is increasingly recognized in clinical practice, especially in older adults. Although each condition has distinct pathophysiologic and imaging features, their association could be challenging for interpretation of imaging and diagnosis. This report presents a series of clinical cases that illustrate multimodality imaging findings in patients with coexisting CAD and ATTR-CM. It highlights the unique and overlapping features seen on echocardiography, cardiac magnetic resonance imaging, nuclear imaging, and coronarography. Special attention is given to diagnosis challenges that arise when these conditions coexist, and to the value of recognizing atypical findings of both CAD and ATTR-CM. The objectives of this report are to: 1) raise awareness of the possibility of ATTR-CM in patients with known CAD; and 2) discuss several specific multi-imaging features and specific findings encountered in clinical cases with concomitant CAD and ATTR-CM.

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Publication Details

Journal
CJC Open
Published
2025-10-25
DOI
https://doi.org/10.1016/j.cjco.2025.10.004
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

Concomitant Cardiac Transthyretin Amyloidosis and Coronary Artery Disease---Imaging Features and Pitfalls

Philippe Pîbarot, Tomas Cieza, Erwan Salaün, Jean‐Michel Paradis et al.
CJC Open
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Concomitant Cardiac Transthyretin Amyloidosis and Coronary Artery Disease---Imaging Features and Pitfalls

Philippe Pîbarot, Tomas Cieza, Erwan Salaün, Jean‐Michel Paradis, Michel Tessier, Julien Ternacle, Marie-Annick A Clavel, Jonathan Beaudoin, Andréanne Powers, Mathieu Bernier, Nicolas Lavoie, Mohamed Marzouk, Alexis Jacquier, Nancy Côté, Élisabeth Bédard, Kim O’Connor, Francis Morin, Omar Idrissi
article en

Abstract

The coexistence of coronary artery disease (CAD) and transthyretin cardiac amyloidosis (ATTR-CM) is increasingly recognized in clinical practice, especially in older adults. Although each condition has distinct pathophysiologic and imaging features, their association could be challenging for interpretation of imaging and diagnosis. This report presents a series of clinical cases that illustrate multimodality imaging findings in patients with coexisting CAD and ATTR-CM. It highlights the unique and overlapping features seen on echocardiography, cardiac magnetic resonance imaging, nuclear imaging, and coronarography. Special attention is given to diagnosis challenges that arise when these conditions coexist, and to the value of recognizing atypical findings of both CAD and ATTR-CM. The objectives of this report are to: 1) raise awareness of the possibility of ATTR-CM in patients with known CAD; and 2) discuss several specific multi-imaging features and specific findings encountered in clinical cases with concomitant CAD and ATTR-CM.

CJC OpenVol. 8(2)
Aix-Marseille Université (FR), Hôpital Cardiologique du Haut-Lévêque (FR), Institut universitaire de cardiologie et de pneumologie de Québec (CA), Centrale Méditerranée (FR), Université Laval (CA), McGill University (CA)
Edwards Lifesciences
Openalex Percentile: Top 73%
Amyloidosis: Diagnosis, Treatment, Outcomes
DOIOpen Access PDFOpenAlex
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