Functional stability of the second mitotic spindle in blastomeres and its association with multinucleation repair
Observations of mitotic spindle morphology and chromosomal segregation behavior revealed that second mitosis is less prone to chromosomal segregation errors than first mitosis. This suggests that segregation errors occurring during the first mitosis may be corrected during the second mitosis. Furthermore, there was no association between the nuclear status during early embryonic divisions and the chromosomal status of blastocyst cells, suggesting the presence of a mechanism that corrects chromosomal abnormalities during early development.
Authors
- Yohei Onodera (ORCID: https://orcid.org/0000-0002-2357-8804)
- Motonari Okabe (ORCID: https://orcid.org/0000-0002-5578-6800)
- Yuki Ono (ORCID: https://orcid.org/0009-0003-8083-7555)
- Yukiyo Kumazawa
- Takeo Hirakawa (ORCID: https://orcid.org/0000-0003-2085-3927)
- Kenichi Makino (ORCID: https://orcid.org/0000-0002-0359-3038)
- Chika Ariake
- Hiromitsu Shirasawa (ORCID: https://orcid.org/0000-0001-5300-0037)
- Yoshimasa Asada (ORCID: https://orcid.org/0000-0002-0448-9953)
- Takuya Iwasawa (ORCID: https://orcid.org/0000-0001-7912-9349)
- Taichi Sakaguchi
- Tae Sugawara
- Noritaka Fukunaga (ORCID: https://orcid.org/0000-0003-2161-3319)
- Ayaka Fujishima
- Kazumasa Takahashi (ORCID: https://orcid.org/0000-0001-5424-7736)
- Hiroshi Miura (ORCID: https://orcid.org/0000-0002-4623-6970)
- Yukihiro Terada (ORCID: https://orcid.org/0000-0003-2392-5498)
- Mayumi Goto
- Asuka Tsuya
Institutions
- Akita University (JP)
Publication Details
- Journal
- F&S Science
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.xfss.2025.10.003
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00