Comparison of 3 vs 5 Fraction Single Isocenter Radiosurgery for Brain Metastases
In this study, 9 Gy × 3 fx for brain metastases had improved tumor control and comparable toxicity to 6 Gy × 5, particularly among tumors <2 cm. 9 Gy × 3 fx may be the preferred regimen when treating multiple tumors with one prescription using single isocenter radiosurgery as it improves efficiency and local control while having similar toxicity.
Authors
- Joel A. Pogue (ORCID: https://orcid.org/0000-0003-4450-6698)
- M.C. Dobelbower (ORCID: https://orcid.org/0000-0003-0847-3016)
- Kristen Owen Riley (ORCID: https://orcid.org/0000-0001-5895-6855)
- Drexell H. Boggs (ORCID: https://orcid.org/0000-0003-1046-1671)
- Richard A. Popple (ORCID: https://orcid.org/0000-0003-1252-738X)
- Samuel Marcrom (ORCID: https://orcid.org/0000-0002-4014-3781)
- James M. Markert (ORCID: https://orcid.org/0000-0001-7457-7329)
- Christopher D. Willey (ORCID: https://orcid.org/0000-0001-9953-0279)
- Roman Travis (ORCID: https://orcid.org/0000-0002-5133-9245)
- Rodney J. Sullivan
- John B. Fiveash (ORCID: https://orcid.org/0000-0002-1129-2884)
- Luke Moradi (ORCID: https://orcid.org/0000-0002-8055-6388)
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.adro.2025.101927
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00