Early Experience Comparing Reduced Planning Target Volume Margins Using Cone Beam Computed Tomography Scan Guided Online Adaptive Radiation Therapy to Nonadaptive, Traditional Margin Plans for Muscle-Invasive Bladder Cancer
oART achieved acceptable dosimetry for target volumes with a reduced PTV margin of 7 mm, despite considerable daily bladder volume variation. AD treatment plans improved target coverage and OAR dosimetry. Future patient-centered studies should explore the long-term clinical impact of reduced margin of oART for MIBC.
Authors
- Joel A. Pogue (ORCID: https://orcid.org/0000-0003-4450-6698)
- Joseph Harms (ORCID: https://orcid.org/0000-0003-2441-9853)
- Dennis N. Stanley (ORCID: https://orcid.org/0000-0003-4792-748X)
- Whitney S. Hotsinpiller
- Michael Tyler (ORCID: https://orcid.org/0000-0003-2128-5247)
- Carlos E. Cardenas (ORCID: https://orcid.org/0000-0003-1414-3849)
- Andrew McDonald
- Samuel B Hayworth
Institutions
- Washington University in St. Louis (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.adro.2025.101934
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Varian Medical Systems