3D-printed magnetic scaffolds promote bone and vessel regeneration through CRYAB/PI3K-AKT and NF-κB pathways identified by proteomics
Our findings provide direct evidence that 3D-printed PLGA/Fe<sub>2</sub>O<sub>3</sub> scaffolds promote osteogenesis and angiogenesis both <i>in vitro</i> and <i>in vivo</i>. Importantly, we report for the first time that CRYAB-mediated stabilization of β-catenin plays a central role in magnetic scaffold-induced bone regeneration, offering new insights into the design of functional bone substitutes.
Authors
- Yue Huang (ORCID: https://orcid.org/0000-0001-6923-9325)
- Cairong Li (ORCID: https://orcid.org/0000-0002-3151-0607)
- Zhengyao Li (ORCID: https://orcid.org/0000-0002-0149-5864)
- Tianle Li
- Fuze Liu
- Yuxiao Lai (ORCID: https://orcid.org/0000-0002-8648-6595)
- Hui Chen (ORCID: https://orcid.org/0000-0003-0957-2964)
- Hai Wang (ORCID: https://orcid.org/0000-0003-1453-855X)
- Zhihong Wu (ORCID: https://orcid.org/0000-0002-1902-4198)
- Jieying Liu (ORCID: https://orcid.org/0000-0001-9041-3834)
- Y.-S. Wu (ORCID: https://orcid.org/0000-0003-0230-4705)
- Di Wu (ORCID: https://orcid.org/0009-0009-7526-8961)
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Prince Philip Dental Hospital (CN)
- Manufacturing Institute (US)
- Shanghai Sixth People's Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.bioactmat.2025.10.013
- Citations
- 1
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.67