Ythdf2 loss in microglia aggravates ischemic retinopathy by increasing microglia activation and microvascular anomalies
Loss of Ythdf2 in retinal microglia increased their activation and caused microvascular anomalies through Ace and Bmp4, providing insights into microvascular development and disease mechanisms. These findings suggest potential therapeutic approaches targeting the Ythdf2-Ace/Bmp4 network for microvascular diseases.
Authors
- Jiang-Dong Ji
- Xin Cao (ORCID: https://orcid.org/0000-0001-8787-594X)
- Meidong Zhu (ORCID: https://orcid.org/0000-0002-1192-0537)
- Ye-Ran Zhang
- Songtao Yuan (ORCID: https://orcid.org/0000-0001-9212-0664)
- Qinghuai Liu (ORCID: https://orcid.org/0000-0003-1605-1964)
- Xue Chen (ORCID: https://orcid.org/0009-0009-4919-0187)
- Ying Wang (ORCID: https://orcid.org/0009-0001-9260-2062)
- Bing Qin (ORCID: https://orcid.org/0009-0008-9870-567X)
- Yichen Zhang (ORCID: https://orcid.org/0000-0002-1076-1853)
- Jianan Wang (ORCID: https://orcid.org/0000-0002-4583-3204)
- Hong-Jing Zhu
- Biao Yan (ORCID: https://orcid.org/0009-0007-0063-5718)
- Zi-Qin Ding
Institutions
- Nantong University (CN)
- Shanghai Chest Hospital (CN)
- Affiliated Hospital of Nantong University (CN)
- Organ and Tissue Authority (AU)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.024
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00