Norisoboldine restrains γδT17 cell activation and consequently alleviates psoriasis-like dermatitis in mice by selectively down-regulating glutaminolysis to decrease the level of α-ketoglutarate
NOR can limit γδT17 cell activation to alleviate psoriasis-like dermatitis in mice by suppressing glutaminolysis, down-regulating the levels of α-KG, inhibiting the expression of KDM6b, and consequently increasing the trimethylation level of histone H3K27 in RORγt promoter. These findings attest to the beneficial effect of NOR in inhibiting γδT17 cell activation and offer a potential therapeutic approach for psoriasis.
Authors
- Jian-Y. Fan
- Zhifeng Wei (ORCID: https://orcid.org/0000-0002-9246-9783)
- Yilei Guo (ORCID: https://orcid.org/0000-0001-9283-0543)
- Yanrong Zhu (ORCID: https://orcid.org/0000-0003-4145-9179)
- Yue Dai (ORCID: https://orcid.org/0000-0003-4872-2064)
- Yufeng Xia (ORCID: https://orcid.org/0000-0002-9571-5353)
- Chenxi Li (ORCID: https://orcid.org/0000-0002-7803-8282)
- Yue He (ORCID: https://orcid.org/0000-0001-6859-8270)
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.043
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00