Transcriptomics-driven antiviral drug screening identifies ATF6 as a homeostatic regulator of ER stress and innate immunity
This work positions ER stress modulation, particularly ATF6 targeting, as a strategy to balance antiviral defense and inflammatory toxicity, offering a roadmap for pan-coronavirus therapeutics. With these results, we established a paradigm for transcriptomic signature-based drug screening system for future treatment development of virus pandemics.
Authors
- Yan Zhao (ORCID: https://orcid.org/0000-0002-3087-4767)
- Yuhui Hu (ORCID: https://orcid.org/0000-0002-5210-5301)
- Shizhong Bu (ORCID: https://orcid.org/0000-0001-5196-6030)
- Jincun Zhao (ORCID: https://orcid.org/0000-0003-2515-5589)
- Qinan Hu (ORCID: https://orcid.org/0000-0003-3653-3004)
- Ruoqing Feng
- Yuan He (ORCID: https://orcid.org/0000-0001-9809-9472)
- Jing Sun (ORCID: https://orcid.org/0000-0002-5543-803X)
- Zhenyu Yang (ORCID: https://orcid.org/0000-0002-1652-5667)
- Yanhong Tang (ORCID: https://orcid.org/0009-0000-4826-6017)
Institutions
- Southern University of Science and Technology (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.036
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00