Clinical validation of a multi-model blood cfDNA methylation assay for early-stage gastrointestinal cancer screening
This study introduced a novel, dual-model blood architecture (SPOGIT/CSO) that enables highly accurate, early detection of GI cancers and their precursors. By facilitating timely clinical intervention, SPOGIT/CSO represented a paradigm-shifting strategy with the potential to significantly improve patient survival outcomes and transform GI cancer management.
Authors
- Ruiru Wang
- Shuyang Sun (ORCID: https://orcid.org/0000-0001-6013-0614)
- Jianwei Yu
- Lijuan Lin (ORCID: https://orcid.org/0000-0002-8305-0294)
- Shuye Lin (ORCID: https://orcid.org/0000-0002-4292-0302)
- Mengyu Jia (ORCID: https://orcid.org/0000-0002-3920-0881)
- Dongliang Yu (ORCID: https://orcid.org/0000-0003-3626-0296)
- Qiaoqiao Lin (ORCID: https://orcid.org/0009-0002-5801-2162)
- Shiqian Lan
- Wei Guo (ORCID: https://orcid.org/0000-0002-9924-638X)
- Lei Zhu (ORCID: https://orcid.org/0000-0002-1800-4769)
- Jianqiu Sheng (ORCID: https://orcid.org/0000-0002-9455-0198)
- Xianzong Ma (ORCID: https://orcid.org/0000-0002-0419-6800)
- Yi Xiang (ORCID: https://orcid.org/0000-0002-0724-6359)
- Hui Xie (ORCID: https://orcid.org/0000-0003-4322-7267)
- Xin Wang (ORCID: https://orcid.org/0000-0002-5778-9212)
- Peng Jin (ORCID: https://orcid.org/0000-0001-6685-1906)
- Shu Li (ORCID: https://orcid.org/0000-0002-3393-4390)
- Chenguang Li (ORCID: https://orcid.org/0000-0002-2783-2259)
- Ju Tian
- Junfeng Xu
- Ni Guo (ORCID: https://orcid.org/0000-0001-9115-650X)
- Qian Kang (ORCID: https://orcid.org/0000-0002-9624-5111)
- Xueqin Lin
- Linghui Duan
- Xueqing Gong (ORCID: https://orcid.org/0009-0003-1268-4374)
- Fangli Men
- Yuqi He (ORCID: https://orcid.org/0009-0000-1483-9139)
Institutions
- Fujian Medical University (CN)
- Longyan University (CN)
- Wenzhou Medical University (CN)
- Chinese PLA General Hospital (CN)
- Shanghai CASB Biotechnology (China) (CN)
- Beijing Chest Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Dongyang People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.038
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00