Berberine suppresses colorectal cancer progression by inducing ferroptosis-mediated energy metabolism disorders
BBR triggers ferroptosis-mediated energy metabolism disorder by inhibiting Gli1/STAT3-FNR axis. This work provides a mechanistic support for BBR anti-CRC indications, and suggests an encouraging approach for treating CRC.
Authors
- Sang‐Kuk Yang (ORCID: https://orcid.org/0000-0002-7377-0992)
- Lulu Cai (ORCID: https://orcid.org/0000-0002-5678-1112)
- Yan Li (ORCID: https://orcid.org/0000-0002-9402-1093)
- Qiang Sun (ORCID: https://orcid.org/0000-0002-2556-1803)
- Hongmei Liu (ORCID: https://orcid.org/0000-0003-1064-2448)
- Jingxuan Wang (ORCID: https://orcid.org/0000-0003-0380-6352)
- Lin Lv (ORCID: https://orcid.org/0000-0002-5253-1669)
- Qiqi Xu (ORCID: https://orcid.org/0009-0000-7685-5572)
- Ke-Rong Tu
Institutions
- University of Electronic Science and Technology of China (CN)
- Southwest Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.025
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56