Protective Role for Itaconate During Inhaled Allergen Challenge
Levels of itaconate are altered after allergen challenge in mild asthmatics and in murine models of disease. Itaconate deficiency did not alter house dust mite-induced pathology at any of the timepoints tested; however, inhaled itaconate ameliorated inflammatory responses to inhaled allergen.
Authors
- Simone A. Walker
- John M. Halket (ORCID: https://orcid.org/0000-0003-2767-303X)
- A. G. Caldwell
- Gail M. Gauvreau (ORCID: https://orcid.org/0000-0002-6187-2385)
- Patricia P. Ogger (ORCID: https://orcid.org/0000-0002-2698-3565)
- Paul M. O’Byrne (ORCID: https://orcid.org/0000-0003-0979-281X)
- Cormac McCarthy (ORCID: https://orcid.org/0000-0003-2896-5210)
- Timothy Hinks (ORCID: https://orcid.org/0000-0003-0699-2373)
- Gesa J. Albers (ORCID: https://orcid.org/0000-0002-8249-6956)
- Helen O’Brien (ORCID: https://orcid.org/0000-0002-6406-1860)
- Karen Duvall
- Lisha Joshi (ORCID: https://orcid.org/0000-0003-2714-6686)
- Adam J. Byrne (ORCID: https://orcid.org/0000-0003-2736-8174)
- Clare M. Lloyd (ORCID: https://orcid.org/0000-0001-8977-6726)
- Helen Stölting (ORCID: https://orcid.org/0000-0002-7830-2776)
- Christina Michalaki
- Alia Batool (ORCID: https://orcid.org/0000-0002-3771-6067)
Institutions
- University College Dublin (IE)
- King's College London (GB)
- National Institute for Health and Care Research (GB)
- NIHR Southampton Respiratory Biomedical Research Unit (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Imperial College London (GB)
- McMaster University (CA)
Publication Details
- Journal
- Allergy
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1111/all.70107
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Asthma and Lung UK
- Imperial College London
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Medical Research Council