Targeting the muscle-brain axis to improve post-stroke cognition via the FNDC5/irisin/BDNF pathway
Hemiplegic muscle atrophy contributes to PSCI through the FNDC5/irisin/BDNF axis downregulation. Elevating irisin shows therapeutic potential for PSCI.
Authors
- Weixian Huang (ORCID: https://orcid.org/0000-0001-9995-2631)
- Zhiyi Xiong (ORCID: https://orcid.org/0000-0002-3475-907X)
- Dingxiang Xie
- Yingxin He (ORCID: https://orcid.org/0000-0003-2543-4553)
- Zimu Jiang (ORCID: https://orcid.org/0000-0002-5995-4859)
- Lisi Zha
- Jinsheng Zeng (ORCID: https://orcid.org/0000-0003-4280-0439)
- Yuangui Cai
- Miaoxian Yang (ORCID: https://orcid.org/0000-0001-7429-5276)
- Fubing Ouyang
- Jianle Li
- Jia Xie (ORCID: https://orcid.org/0000-0003-0218-1530)
- Xiya Long
- Jiating Wei
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.027
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16