Paradoxical ileocecal perforation during early anti-tuberculosis therapy: A rare case report

This case highlights the importance of recognizing paradoxical reactions, such as intestinal perforation, as potential complications during the early phase of anti-tubercular therapy. Maintaining early vigilance and a high index of suspicion is essential for timely diagnosis and appropriate intervention. Clinicians should consider paradoxical perforation in patients who deteriorate shortly after initiating anti-TB treatment, even when adherence is confirmed. Early surgical intervention, guided by a high index of suspicion, is crucial to reducing morbidity and improving outcomes in intestinal tuberculosis.

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Publication Details

Journal
International Journal of Surgery Case Reports
Published
2025-10-25
DOI
https://doi.org/10.1016/j.ijscr.2025.112100
Primary Topic
Diagnosis and treatment of tuberculosis
Type
article
Field-Weighted Citation Impact
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article

Paradoxical ileocecal perforation during early anti-tuberculosis therapy: A rare case report

Binyam M Habte, Solomon Abebe Yimer, Yemiserach Kifle, Esimael M Abdu et al.
International Journal of Surgery Case Reports
Diagnosis and treatment of tuberculosis
article

Paradoxical ileocecal perforation during early anti-tuberculosis therapy: A rare case report

Binyam M Habte, Solomon Abebe Yimer, Yemiserach Kifle, Esimael M Abdu, Yoseph M Habte, Makida M Habte
article en

Abstract

This case highlights the importance of recognizing paradoxical reactions, such as intestinal perforation, as potential complications during the early phase of anti-tubercular therapy. Maintaining early vigilance and a high index of suspicion is essential for timely diagnosis and appropriate intervention. Clinicians should consider paradoxical perforation in patients who deteriorate shortly after initiating anti-TB treatment, even when adherence is confirmed. Early surgical intervention, guided by a high index of suspicion, is crucial to reducing morbidity and improving outcomes in intestinal tuberculosis.

International Journal of Surgery Case ReportsVol. 137
St. Paul's Hospital Millennium Medical College (ET), Addis Ababa University (ET), University of Gondar (ET)
Openalex Percentile: Top 52%
Diagnosis and treatment of tuberculosis
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Paradoxical ileocecal perforation during early anti-tuberculosis therapy: A rare case report — Binyam M Habte, Solomon Abebe Yimer, et al. · International Journal of Surgery Case Reports (2025) | TGRS Research Map | TGRS