A synergistic multimodality treatment approach to address the key drivers of wound chronicity
Chronic wounds persist due to a self-sustaining cycle of hypoxia, edema, and inflammation. By integrating oxygen delivery with cyclical compression, ITOT directly addresses the multifactorial barriers to repair, promoting durable healing and reducing complications. This multi-modality approach represents a promising therapeutic advance in the management of refractory lower extremity wounds, with broad implications for improving outcomes and quality of life and reducing health care costs.
Authors
- J.D. Raffetto
- Melodie Blakely (ORCID: https://orcid.org/0000-0001-7000-884X)
- Kathleen J. Ozsvath
- Michael Edmonds (ORCID: https://orcid.org/0000-0002-8931-0069)
- David Dexter (ORCID: https://orcid.org/0000-0003-1366-3906)
- Joann M. Lohr
- Matthew Regulski
Institutions
- Partners In Health (US)
- Eastern Virginia Medical School (US)
- King's College London (GB)
- Wm. Jennings Bryan Dorn VA Medical Center (US)
- VA Boston Healthcare System (US)
- Ocean County College (US)
- Eotron (United States) (US)
- American Orthopaedic Foot and Ankle Society (US)
- King's College School (GB)
- Oceanside Public Library (US)
Publication Details
- Journal
- Journal of Vascular Surgery Venous and Lymphatic Disorders
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.jvsv.2025.102348
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs