Insights into the Role of Rifampicin Exposure and Clinical Baseline Covariates on the Response to Pulmonary Tuberculosis Treatment

Our findings highlight the role of rifampicin plasma exposure in optimizing bacillary clearance and improving treatment outcomes, even within standard dosing regimens for drug-susceptible tuberculosis.

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Publication Details

Journal
Clinical Infectious Diseases
Published
2025-10-22
DOI
https://doi.org/10.1093/cid/ciaf586
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Insights into the Role of Rifampicin Exposure and Clinical Baseline Covariates on the Response to Pulmonary Tuberculosis Treatment

Richard Court, Tara Carney, Karen R. Jacobson, Robin M. Warren et al.
Clinical Infectious Diseases
Tuberculosis Research and Epidemiology
article

Insights into the Role of Rifampicin Exposure and Clinical Baseline Covariates on the Response to Pulmonary Tuberculosis Treatment

Richard Court, Tara Carney, Karen R. Jacobson, Robin M. Warren, Helen McIlleron, Frank Kloprogge, Sanjana G. Kulkarni, Samantha Malatesta, Charles Parry, Suchitra Kulkarni, Maha Reda Farhat, Paolo Denti, Marie Wijk, Laura F. White, BRONWYN J. MYERS, C. Robert Horsburgh, Kamunkhwala Gausi, Sarah E Weber, C. Buys, Danie Theron, Noorjahn Rawoot
article en

Abstract

Our findings highlight the role of rifampicin plasma exposure in optimizing bacillary clearance and improving treatment outcomes, even within standard dosing regimens for drug-susceptible tuberculosis.

Clinical Infectious Diseases
South African Medical Research Council (ZA), Boston University (US), Boston Medical Center (US), Harvard University (US), Desmond Tutu HIV Foundation (ZA), University of Cape Town (ZA), Curtin University (AU), University of Johannesburg (ZA), Stellenbosch University (ZA), Life Groenkloof Hospital (ZA), Worcester Memorial Hospital (US), Massachusetts General Hospital (US), University College London (GB)
Openalex Percentile: Top 64%
Tuberculosis Research and Epidemiology
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