Insights into the Role of Rifampicin Exposure and Clinical Baseline Covariates on the Response to Pulmonary Tuberculosis Treatment
Our findings highlight the role of rifampicin plasma exposure in optimizing bacillary clearance and improving treatment outcomes, even within standard dosing regimens for drug-susceptible tuberculosis.
Authors
- Richard Court (ORCID: https://orcid.org/0000-0002-7927-6506)
- Tara Carney (ORCID: https://orcid.org/0000-0001-5400-0565)
- Karen R. Jacobson (ORCID: https://orcid.org/0000-0003-4239-3685)
- Robin M. Warren (ORCID: https://orcid.org/0000-0001-5741-7358)
- Helen McIlleron (ORCID: https://orcid.org/0000-0002-0982-6226)
- Frank Kloprogge (ORCID: https://orcid.org/0000-0001-7213-4559)
- Sanjana G. Kulkarni (ORCID: https://orcid.org/0000-0002-9883-610X)
- Samantha Malatesta (ORCID: https://orcid.org/0000-0003-0849-2348)
- Charles Parry (ORCID: https://orcid.org/0000-0001-9787-2785)
- Suchitra Kulkarni
- Maha Reda Farhat (ORCID: https://orcid.org/0000-0002-3871-5760)
- Paolo Denti (ORCID: https://orcid.org/0000-0001-7494-079X)
- Marie Wijk (ORCID: https://orcid.org/0000-0001-6013-8210)
- Laura F. White (ORCID: https://orcid.org/0000-0002-0588-8235)
- BRONWYN J. MYERS (ORCID: https://orcid.org/0000-0003-0235-6716)
- C. Robert Horsburgh (ORCID: https://orcid.org/0000-0001-6838-7895)
- Kamunkhwala Gausi (ORCID: https://orcid.org/0000-0002-9002-8087)
- Sarah E Weber (ORCID: https://orcid.org/0000-0001-5828-8500)
- C. Buys (ORCID: https://orcid.org/0000-0003-3284-7823)
- Danie Theron
- Noorjahn Rawoot
Institutions
- South African Medical Research Council (ZA)
- Boston University (US)
- Boston Medical Center (US)
- Harvard University (US)
- Desmond Tutu HIV Foundation (ZA)
- University of Cape Town (ZA)
- Curtin University (AU)
- University of Johannesburg (ZA)
- Stellenbosch University (ZA)
- Life Groenkloof Hospital (ZA)
- Worcester Memorial Hospital (US)
- Massachusetts General Hospital (US)
- University College London (GB)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1093/cid/ciaf586
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00