Neurosymptomatic Cerebrospinal Fluid Escape Is a Central Nervous System–Focused Form of Antiretroviral Therapy Treatment Failure
NSE and NSE-h are driven by replication of drug-resistant HIV-1 in CD4+ T cells in the CNS, with NSE-h having higher CSF viral loads reflecting more HIV-1 replication. This suggests that people presenting with neurologic symptoms and treatment failure may be experiencing CNS-focused treatment failure that could require specialized treatment.
Authors
- Laura P. Kincer
- Ameet Dravid (ORCID: https://orcid.org/0000-0002-1909-7530)
- Magnus Gisslén (ORCID: https://orcid.org/0000-0002-2357-1020)
- Riccardo Vercesi
- Sarah Joseph (ORCID: https://orcid.org/0000-0001-9603-574X)
- Richard W. Price (ORCID: https://orcid.org/0000-0001-5429-6044)
- Shuntai Zhou (ORCID: https://orcid.org/0000-0002-8353-386X)
- Serena Spudich (ORCID: https://orcid.org/0000-0001-6032-3950)
- Paola Cinque (ORCID: https://orcid.org/0000-0003-2448-5957)
Institutions
- University of North Carolina at Chapel Hill (US)
- Public Health Agency of Sweden (SE)
- Vita-Salute San Raffaele University (IT)
- University of California, San Francisco (US)
- Sahlgrenska University Hospital (SE)
- Yale University (US)
- ACE Hospital (IN)
- Region Västra Götaland (SE)
- Noble Hospital (IN)
- University of Gothenburg (SE)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1093/ofid/ofaf659
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Center for AIDS Research, University of Washington
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Center for AIDS Research, University of North Carolina at Chapel Hill