Metabolic regulation of T cell production of IL-10 and IL-22 protects against intestinal inflammation
Our findings demonstrate that DCA enhances IL-22 and IL-10 production in Th1 cells through Ahr and Bhlhe40, respectively. These results identify a novel metabolic mechanism by which DCA promotes mucosal immune regulation and highlight its potential as a therapeutic strategy for inflammatory bowel disease.
Authors
- Yingzi Cong (ORCID: https://orcid.org/0000-0003-4167-7395)
- Yu Yu (ORCID: https://orcid.org/0000-0002-8341-5994)
- Xiaojing Zhao (ORCID: https://orcid.org/0000-0001-5571-9192)
- Wenjing Yang (ORCID: https://orcid.org/0000-0003-2990-9341)
- Suxia Yao
- Tianming Yu (ORCID: https://orcid.org/0009-0005-1897-633X)
- Han Liu (ORCID: https://orcid.org/0000-0003-4476-2253)
Institutions
- Northwestern University (US)
- Northwestern University (PH)
- Northwestern Medicine (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Precision Clinical Medicine
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1093/pcmedi/pbaf025
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00