Xylazine, a Nonopioid Sedative and Public Health Crisis—An Overview

<h2>Abstract</h2> There has been a recent emergence of xylazine adulteration within the community drug supply. Xylazine use can precipitate central nervous system depression, hypotension, bradycardia, and respiratory depression, and these effects are further potentiated when combined with fentanyl or other opioids, escalating the risk of fatal respiratory depression. Furthermore, xylazine use is associated with necrotizing and treatment refractory wounds. Nurse practitioners across the care continuum must be aware of xylazine and associated management strategies. The purpose of this review is to provide nurse practitioners with the necessary information needed to provide high-quality care to those affected by xylazine use and associated sequelae.