Sarcopenic diabetes is an under-recognized and unmet clinical priority. A call for action from the European Society for Clinical Nutrition and Metabolism and the Diabetes Nutrition Study Group

Diabetes mellitus is a systemic chronic disease with growing prevalence and potential multiorgan complications leading to clinical, social, and economic burdens. Nutritional and metabolic derangements are important components of both type 1 (T1DM) and type 2 diabetes (T2DM), but assessment of nutritional state, body composition and muscle function is commonly neglected. Likely reasons include high prevalence of overweight, obesity, or excess visceral fat in highly-prevalent T2DM, potentially diverting attention from undernutrition risk. Diabetes and adiposity are mechanistically related to sarcopenia, defined as reduction of skeletal muscle strength and mass, through complex muscle-catabolic derangements, conferring additional risk for negative outcomes. Awareness of diabetes-induced muscle abnormalities remains low among healthcare professionals, patients and policymakers, contributing to research, knowledge and practice gaps. Lifestyle recommendations and treatments centered on nutritional care and physical activity to preserve and improve muscle mass and function remain poorly implemented. The European Society for Clinical Nutrition and Metabolism (ESPEN) and the Diabetes Nutrition Study Group (DNSG), reference group for the European Association for the Study of Diabetes, recognize sarcopenic diabetes as a distinct clinical condition and priority for research and education, and call for action to enhance awareness, stimulate research and promote consensus on sarcopenic diabetes diagnostic criteria, prevention and management.

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Publication Details

Journal
Clinical Nutrition
Published
2025-10-25
DOI
https://doi.org/10.1016/j.clnu.2025.10.007
Citations
1
Primary Topic
Nutrition and Health in Aging
Type
article
Field-Weighted Citation Impact
1.16
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article

Sarcopenic diabetes is an under-recognized and unmet clinical priority. A call for action from the European Society for Clinical Nutrition and Metabolism and the Diabetes Nutrition Study Group

Lorenzo M. Donini, John L. Sievenpiper, Hana Kahleová, S. Schneider et al.
1 citations
Clinical Nutrition
Nutrition and Health in Aging
1.16
article

Sarcopenic diabetes is an under-recognized and unmet clinical priority. A call for action from the European Society for Clinical Nutrition and Metabolism and the Diabetes Nutrition Study Group

Lorenzo M. Donini, John L. Sievenpiper, Hana Kahleová, S. Schneider, Jordi Salas‐Salvadó, Laura Chiavaroli, Tommy Cederholm, Ursula Schwab, Annalisa Giosuè, Cristina Cuerda, María D. Ballesteros‐Pomar, Anne‐Marie Aas, Nicolaas E.P. Deutz, M. León‐Sanz, Jeffrey I. Mechanick, Rocco Barazzoni, Charilaos Dimosthenopoulos, Gabriele Riccardi, Yves Boirie‌, Laurence Genton, Cyril W.C. Kendall, Stanisław Kłęk
article en
1 citations

Abstract

Diabetes mellitus is a systemic chronic disease with growing prevalence and potential multiorgan complications leading to clinical, social, and economic burdens. Nutritional and metabolic derangements are important components of both type 1 (T1DM) and type 2 diabetes (T2DM), but assessment of nutritional state, body composition and muscle function is commonly neglected. Likely reasons include high prevalence of overweight, obesity, or excess visceral fat in highly-prevalent T2DM, potentially diverting attention from undernutrition risk. Diabetes and adiposity are mechanistically related to sarcopenia, defined as reduction of skeletal muscle strength and mass, through complex muscle-catabolic derangements, conferring additional risk for negative outcomes. Awareness of diabetes-induced muscle abnormalities remains low among healthcare professionals, patients and policymakers, contributing to research, knowledge and practice gaps. Lifestyle recommendations and treatments centered on nutritional care and physical activity to preserve and improve muscle mass and function remain poorly implemented. The European Society for Clinical Nutrition and Metabolism (ESPEN) and the Diabetes Nutrition Study Group (DNSG), reference group for the European Association for the Study of Diabetes, recognize sarcopenic diabetes as a distinct clinical condition and priority for research and education, and call for action to enhance awareness, stimulate research and promote consensus on sarcopenic diabetes diagnostic criteria, prevention and management.

Clinical NutritionVol. 55
Uppsala University (SE), Sapienza University of Rome (IT)
Openalex Percentile: Top 17%
Nutrition and Health in Aging
1.16
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