Relative biological effectiveness and neural stem cell fate in carbon ion–irradiated human brain organoids
Our findings indicate that aberrant CP development is a central mechanism underlying post-radiation contrast-enhanced brain lesions, and that an RBE of 2 should be considered when determining dose thresholds for normal tissue tolerance in carbon ion therapy for brain tumors.
Authors
- Tamara Bender (ORCID: https://orcid.org/0000-0003-4504-2012)
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- Insa S. Schroeder (ORCID: https://orcid.org/0000-0002-3957-7099)
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1016/j.radonc.2025.111224
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Johannes Gutenberg-Universität Mainz
- National Institutes of Health