The Effects of Fasinumab on Peripheral Nerve Function and Ganglion Anatomy: Results From a Randomized, Double-Blind, Placebo-Controlled Study in Patients With Pain Due to Osteoarthritis of the Knee or Hip, and a Series of Nonclinical Studies
No clinically meaningful differences were observed between fasinumab- and placebo-treated patients for nerve conduction velocities and action potential amplitudes. In the nonclinical studies, no significant changes could be detected in adult rat ganglion anatomical parameters or hemodynamic parameters at a variety of fasinumab doses. Results from these studies demonstrated that fasinumab did not affect the tested nervous system parameters in adult humans or rats.Trial registration number: NCT02447276; https://clinicaltrials.gov/study/NCT02447276.
Authors
- Simon Eng (ORCID: https://orcid.org/0009-0001-4964-5729)
- Pamela Krueger (ORCID: https://orcid.org/0000-0002-6166-7189)
- Jesus Trejos (ORCID: https://orcid.org/0000-0003-4816-8139)
- Lynn E. Macdonald (ORCID: https://orcid.org/0000-0002-2547-4523)
- Yamini Patel (ORCID: https://orcid.org/0000-0003-0095-2231)
- Jingning Mei
- Paula Dakin (ORCID: https://orcid.org/0000-0002-8925-0414)
- Hazem E. Hassan (ORCID: https://orcid.org/0000-0002-8633-3636)
- Haitao Gao
- Gregory P. Geba (ORCID: https://orcid.org/0000-0001-8936-748X)
- Ngan Trinh
- Luz Cortes-Burgos
- Susan D. Croll (ORCID: https://orcid.org/0000-0002-3949-1877)
- Michael R. Fetell (ORCID: https://orcid.org/0000-0002-4607-4334)
- Stephen J. DiMartino (ORCID: https://orcid.org/0009-0001-0592-7644)
- Garen Manvelian
- Ned Braunstein
- K. C. Turner
- Tina Ho
- Randy Soltys
Institutions
- Regeneron (United States) (US)
- Teva Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Current Therapeutic Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.curtheres.2025.100813
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00