p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression and Progression That Can Be Reversed by Senolytic Therapy
Senescent cells accumulate in the tumor and stroma throughout prostate cancer progression and are associated with immune suppression in patients and mice. Senolytic strategies to clear p21+ senescent stromal cells can prevent prostate cancer progression and reactive cytotoxic T-cell immunity to potentiate anti-PD-1 ICB in advanced disease.
Authors
- Tianyi Ye (ORCID: https://orcid.org/0000-0002-8242-5242)
- Kelly D. DeMarco (ORCID: https://orcid.org/0009-0007-0469-7932)
- Karl Simin (ORCID: https://orcid.org/0000-0002-7431-0939)
- Boyang Ma (ORCID: https://orcid.org/0000-0001-5214-2471)
- Nikita Bhalerao (ORCID: https://orcid.org/0009-0007-1633-4389)
- Hong Wu (ORCID: https://orcid.org/0000-0001-7545-7919)
- Calvin M. Johnson (ORCID: https://orcid.org/0000-0001-5213-5917)
- Junhui Li (ORCID: https://orcid.org/0000-0003-3973-1700)
- Jason R. Pitarresi (ORCID: https://orcid.org/0000-0001-9549-4768)
- Lihua Julie Zhu (ORCID: https://orcid.org/0000-0001-7416-0590)
- Chaitanya Naimesh Parikh (ORCID: https://orcid.org/0000-0003-2728-3998)
- Shi Bai (ORCID: https://orcid.org/0000-0001-6428-1487)
- Katherine C. Murphy (ORCID: https://orcid.org/0000-0002-5962-9896)
- Marcus Ruscetti (ORCID: https://orcid.org/0000-0002-4394-2087)
- J. Li
- Lin Zhou (ORCID: https://orcid.org/0000-0003-2581-4345)
- Bin Liu (ORCID: https://orcid.org/0000-0002-3168-8456)
- Zhong Jiang (ORCID: https://orcid.org/0000-0002-0822-3298)
- Z. Wu (ORCID: https://orcid.org/0009-0005-5302-2339)
- Hadiya K. Giwa (ORCID: https://orcid.org/0009-0003-9541-8919)
Institutions
- University of Massachusetts Chan Medical School (US)
- Peking University (CN)
- Shenzhen Bay Laboratory (CN)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-1212
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80