UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of <i>Persea cordata</i> (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

This study aimed to establish the chemical profile and evaluate the anti-oedematogenic and analgesic activities of the hydroalcoholic extract (HEPC) of Persea cordata bark. In the oedema model induced by carrageenan (CAR), HEPC, exhibited inhibitory effects after 60 min, with maximum inhibition (MI) reaching 89.55 ± 3.17% at 240 min (dose of 100 mg/kg). At doses of 30 and 100 mg/kg, it showed similar effect as meloxicam (3 mg/kg) after 24 h of treatment. In the model of capsaicin-induced oedema (PCS), HEPC displayed MI of 86.23 ± 8.6% during 24 h at 100 mg/kg while meloxicam displayed similar activity at 3 mg/kg. HEPC UPLC-ESI-MS/MS revealed the presence of 10 compounds with the predominant belonging to lignans. Our results suggest that orally administered HEPC has a non-specific anti-oedematogenic and antinociceptive effects, however, it may be related to the presence of anti-inflammatory metabolites that can regulate redox activity and inflammatory mediators.