Base-Mediated Annulation Strategy to Naphthol Boronic Ester Derivatives
The base-promoted annulation reaction of homophthalic anhydrides with potassium ynone trifluoroborate salts offers a convenient method to access a range of <i>ortho</i>-acylphenol derivatives with complete regiocontrol. The products can be further functionalized chemoselectively by cross-coupling, O-alkylation, and oxidative coupling processes.
Authors
- Joseph P. A. Harrity (ORCID: https://orcid.org/0000-0001-5038-5699)
- Salah M. B. Obaida
Institutions
- Mustansiriyah University (IQ)
- Department of Mathematical Sciences (RU)
- Institute of Mathematical Statistics (US)
- University of Sheffield (GB)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-10-24
- DOI
- https://doi.org/10.1021/acs.joc.5c02223
- Citations
- 2
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 1.87