Novel mutations of maternal effect gene thyroid hormone receptor interactor 13 involved in biparental complete hydatidiform mole

To our knowledge, this is the first report linking biallelic TRIP13 mutations to recurrent BiCHM, indicating its potential role in the pathogenesis. ICSI-assisted reproduction did not improve pregnancy outcomes. Ovarian donation or adoption was recommended.

Authors

Xinyun Yang (ORCID: https://orcid.org/0000-0001-5573-6347)
Yan‐Feng Wang (ORCID: https://orcid.org/0000-0002-5646-4475)
Qitao Zhan (ORCID: https://orcid.org/0000-0003-3590-1688)

Institutions

Gene Therapy Laboratory (FR)
Ministry of Education (TH)
Women's Hospital, School of Medicine, Zhejiang University (CN)
S.P.E.C.I.E.S. (US)

Publication Details

Journal: Medicine
Published: 2025-10-24
DOI: https://doi.org/10.1097/md.0000000000045419
Primary Topic: Gestational Trophoblastic Disease Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Novel mutations of maternal effect gene thyroid hormone receptor interactor 13 involved in biparental complete hydatidiform mole

Xinyun Yang, Yan‐Feng Wang, Qitao Zhan

Oct 24, 2025

Medicine

Gestational Trophoblastic Disease Studies

article

Novel mutations of maternal effect gene thyroid hormone receptor interactor 13 involved in biparental complete hydatidiform mole

Xinyun Yang, Yan‐Feng Wang, Qitao Zhan

October 24, 2025article en

Abstract

To our knowledge, this is the first report linking biallelic TRIP13 mutations to recurrent BiCHM, indicating its potential role in the pathogenesis. ICSI-assisted reproduction did not improve pregnancy outcomes. Ovarian donation or adoption was recommended.

MedicineVol. 104(43)

Gene Therapy Laboratory (FR), Ministry of Education (TH), Women's Hospital, School of Medicine, Zhejiang University (CN), S.P.E.C.I.E.S. (US)

Openalex Percentile: Top 59%

Gestational Trophoblastic Disease Studies

DOI Open Access PDF OpenAlex

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Novel mutations of maternal effect gene thyroid hormone receptor interactor 13 involved in biparental complete hydatidiform mole — Xinyun Yang, Yan‐Feng Wang, et al. · Medicine (2025) | TGRS Research Map | TGRS